Group Abhishek Niroula
Short description
We study clonal hematopoiesis and its health consequences. By combining cutting-edge molecular techniques with novel computational methods, we investigate the mechanisms influencing clonal expansion of blood cells.
Understanding the significance of clonal hematopoiesis
Our research is focussed on understanding the origin and evolution of clonal hematopoiesis and its significance in health and disease. Our aim is to identify novel biomarkers and develop computational models to advance precision medicine and improve diagnostics for blood cancers.
Clonal hematopoiesis refers to a premalignant condition characterized by clonal expansion of mutated blood cells. It is associated with elevated risk of blood malignancies and several age-related diseases, including cardiovascular disorders.
We take a data-driven approach to investigate mechanisms influencing the clonal expansion of blood cells. We develop and apply advanced computational methods to analyze large-scale omic data from biobanks and public repositories. Our work includes comprehensive analyses of somatic variations, transcriptomic and epigenomic profiles, as well as epidemiological data.
We investigate how genetic and environmental factors influence clonal evolution and disease progression. Additionally, we study gene regulatory networks in normal, clonal and malignant hematopoiesis by constructing these networks from large-scale omics data.
Group members
Abhishek Niroula, Principal investigator
Hana Komic, Postdoctoral fellow
Adam Dziulko, Postdoctoral fellow
Yajuan Huang, Doctoral student
Tagore Sanketh Bandaru, Doctoral student
Tânia Peniche, Doctoral student
Frida Svensson, Laboratory assistant
